dr hab. Michał Arabski, prof. UJK

Publications

2024

  • Sikora M, Wasik S, Semaniak J, Drulis-Kawa Z, Wisniewska-Wrona M, Arabski M. Chitosan-based matrix as a carrier for bacteriophages. Applied Microbiology and Biotechnology, 2024, 108, 1-16.
  • Sikora M, Maciejewska B, Drulis-Kawa Z, Hudson SM, Semaniak J, Wisniewska-Wrona M, Arabski M. Chitosan-based matrixes for recombinant protein purification from LPS. Biochemical Engineering Journal, 2024, 203, 109212.
  • 2023

    • Dorotkiewicz-Jach A, Markwitz P, Rachuna J, Arabski M, Drulis-Kawa Z. The impact of agarose immobilization on the activity of lytic Pseudomonas aeruginosa phages combined with chemicals. Appl Microbiol Biotechnol, https://doi.org/10.1007/s00253-022-12349-4.
    • Kus A, Wegierek-Ciuk A, Galczynska K, Wasik S, Lyzwinski O, Arabski M, Kujawinska M. Single-shot polarization phase shifting interferometry applied to studying ampicillin diffusion through Pseudomonas aeruginosa biofilm. Proceedings Volume 12622, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials VI; 126220O https://doi.org/10.1117/12.2673869.
    • Skrzyniarz K, Kuc-Ciepluch D, Lasak M, Arabski M, Sanchez-Nieves J, Ciepluch K. Dendritic systems for bacterial outer membrane disruption as a method of overcoming bacterial multidrug resistance. Biomater. Sci., 2023, 11, 6421-6435.
    • 2022

      • Kosztolowicz T, Dutkiewicz A, Lewandowska K.D, Wasik S, Arabski M. Subdiffusion equation with Caputo fractional derivative with respect to another function in modelling diffusion in a complex system consisting of matrix and channels. Phys. Rev. E, 2022.
        • Kuc-Ciepluch D, Gorzkiewicz M, Pedziwiatr-Werbicka E, Barrios-Gumiel A, Lasak M, Mariak A, Sztandera K, Gomez R, de la Mata J, Lankoff A, Klajnert-Maculewicz B, Bryszewska M, Arabski M, Ciepluch K. The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes. Colloids and Surfaces B: Biointerfaces, 217, 2022.
          • Quintana-Sanchez S, Gomez-Casanova N, Sanchez-Nieves J, Gomez R, Rachuna J, Wasik S, Semaniak J, Maciejewska B, Drulis-Kawa Z, Ciepluch K, de la Mata F.J, Arabski M. The antibacterial effect of PEGylated carbosilane dendrimers on P. aeruginosa alone and in combination with phage-derived endolysin. Int. J. Mol. Sci. 2022, 23, 1873.
          • 2021

            • Galczynska K, Ciepluch K, Kurdziel K, Biehl R, Arabski M. Spectroscopic and Small-angle X-ray scattering analysis of binding between copper(II) -1-allylimidazole complex, a potential anti-tumor agent, and bovine serum albumin. Bioorganic Chemistry 2021; 116: 105327.
            • Markwitz P, Olszak T, Gula G, Kowalska M, Arabski M, Drulis-Kawa Z. Emerging phage resistance in Pseudomonas aeruginosa PAO1 is accompanied by an enhanced heterogeneity and reduced virulence. Viruses. 2021; 13(7):1332.
            • Wegierek-Ciuk A, Arabski M, Ciepluch K, Brzoska K, Lisowska H, Czerwinska M, Stepkowski T, Lis K, Lankoff A. Coralyne radiosensitizes A549 cells by upregulation of CDKN1A expression to attenuate radiation induced G2/M block of the cell cycle. Int. J. Mol. Sci. 2021, 22, 5791.
            • Galczynska K, Rachuna J, Ciepluch K, Kowalska M, Wasik S, Kosztolowicz T, Lewandowska KD, Semaniak J, Kurdziel K, Arabski M. Experimental and theoretical analysis of metal complex diffusion through cell monolayer. Entropy 2021, 23, 360.
            • Rewak-Soroczynska J, Sobierajska P, Targonska S, Piecuch A, Grosman L, Rachuna J, Wasik S, Arabski M, Ogorek R, Wiglusz RJ. New approach to antifungal activity of fluconazole incorporated into the porous 6-anhydro-alfa-L-galacto-beta-D-galactan structures modified with nanohydroxyapatite for chronic-wound treatments-in vitro evaluation. Int. J. Mol. Sci. 2021, 22, 3112.
            • Kuc-Ciepluch D, Ciepluch K, Arabski M. Rodzina bialek gazdermin jako czynnik permeabilizujacy blone komorkowa w procesie pyroptozy/Gasdermin family proteins as a permeabilization factor of cell membrane in pyroptosis process. Postepy Hig Med Dosw 2021, 75, 337-344.
            • Sikora M, Wisniewska-Wrona M, Arabski M. Biomedyczne wlasciwosci chitozanu-zastosowanie w inzynierii tkankowej/Biomedical properties of chitosan - application in tissue engineering. Postepy Hig Med Dosw (online) 2021, 75.
            • 2020

              • Czerwik-Marcinkowska J, Galczynska K, Oszczudlowski J, Massalski A, Semaniak J, Arabski M. Fatty acid methyl esters of the aerophytic cave alga Coccomyxa subglobosa as a source for biodiesel production. Energies 2020, 13(24), 6494.
              • Kosztolowicz T, Metzler R, Wasik S, Arabski M. Modelling experimentally measured of ciprofloxacin antibiotic diffusion in Pseudomonas aeruginosa biofilm formed in artificial sputum medium. PLoS One 2020 Dec 3;15(12):e0243003.
              • Ciepluch K, Biehl R, Bryszewska M, Arabski M. Poly(propylene imine) dendrimers can bind to PEGylated albumin at PEG and albumin surface: biophysical examination of a PEGylated platform to transport cationic dendritic nanoparticles. Biopolymers 2020 Jun 16;e23386.
              • Galczynska K, Drulis-Kawa Z, Arabski M. Antitumor activity of Pt(II), Ru(III) and Cu(II) complexes. Molecules 2020, 25(15), 3492.
              • Ciepluch K, Skrzyniarz K, Zdanska J, Barrios-Gumiel A, Sanchez-Nieves J, de la Mata J, Maciejewska B, Drulis-Kawa Z, Bryszewska M, Arabski M. PEGylation of dendronized silver nanoparticles increases the binding affinity of antimicrobial proteins. Journal of Molecular Liquids 319 (2020) 114339.
              • 2019

                • Olszak T, Danis-Wlodarczyk K, Arabski M, Gula G, Maciejewska B, Wasik S, Lood C, Higgins G, Harvey BJ, Lavigne R, Drulis-Kawa Z. Pseudomonas aeruginosa PA5oct jumbo phage impacts planktonic and biofilm population and reduces its host virulence. Viruses 2019, 11, 1089.
                • Ciepluch K, Skrzyniarz K, Barrios-Gumiel A, Quintana S, Sanchez-Nieves J, De la Mata FJ, Maciejewska B, Drulis-Kawa Z, Arabski M. Dendronized silver nanoparticles as bacterial membrane permeabilizers and their interactions with P. aeruginosa lipopolysaccharides, lysozymes, and phage-derived endolysins. Front. Microbiol. 2019, 10:2771.
                • Ciepluch K, Maciejewska B, Galczynska K, Kuc-Ciepluch D, Bryszewska M, Appelhans D, Drulis-Kawa Z, Arabski M. The influence of cationic dendrimers on antibacterial activity of phage endolysin against P. aeruginosa cells. Bioorganic Chemistry, 2019, 91:103121.
                • Galczynska K, Ciepluch K, Madej L, Kurdziel K, Maciejewska B, Drulis-Kawa Z, Wegierek-Ciuk A, Lankoff A, Arabski M. Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole. Sci Rep. 2019, 9:9777.
                • Adamus-Bialek W, Wawszczak M, Arabski M, Majchrzak M, Gulba M, Jarych D, Parniewski P, Gluszek S. Ciprofloxacin, amoxicillin, and aminoglycosides stimulate genetic and phenotypic changes in uropathogenic Escherichia coli strains. Virulence. 2019, 10:260-276.
                • Arabski M, Stabrawa I, Kubala - Kukus A, Galczynska K, Banas D, Piskorz L, Forma E, Brys M, Rozanski W, Lipinski M. The correlation of crystalline and elemental composition of urinary stones with a history of bacterial infections: TXRF, XRPD and PCR-DGGE studies. European Biophysics Journal 2019, 48:111-118.
                • 2018

                  • Galczynska K, Kurdziel K, Ciepluch K, Rachuna J, Kowalska M, Madej L, Wegierek-Ciuk A, Lankoff A, Arabski M. Synthesis, physicochemical and biological characterization of Ni(II) complex with imidazole-4-acetate anion as new antifungal agent J. Chem. Sci. 2018, 130, 169.
                  • 2017

                    • Olszak T, Shneider MM, Latka A, Maciejewska B, Browning C, Sycheva LV, Cornelissen A, Danis-Wlodarczyk K, Senchenkova SN, Shashkov AS, Gula G, Arabski M, Wasik S, Miroshnikov KA, Lavigne R, Leiman PG, Knirel YA, Drulis-Kawa Z. The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence. Sci Rep. 2017, 24;7(1):16302.
                    • Kubala-Kuku┼Ť A, Arabski M, Stabrawa I, Bana┼Ť D, R├│┼╝a┼äski W, Lipi┼äski M, Majewska U, Wudarczyk-Mo─çko J, Braziewicz J, Pajek M, G├│┼║d┼║ S. Application of TXRF and XRPD techniques for analysis of elemental and chemical composition of human kidney stones. X-Ray Spectrom. 2017, 46, 412-420.
                    • Arabski M, W─ůsik S. Laser interferometry method as a novel tool in endotoxins research. Methods Mol Biol. 2017, 1600:125-132.

                    2016

                    • Danis-Wlodarczyk K, Vandenheuvel D, Jang HB, Briers Y, Olszak T, Arabski M, Wasik S, Drabik M, Higgins G, Tyrrell J, Harvey BJ, Noben JP, Lavigne R, Drulis-Kawa Z. A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections. Sci. Rep. 2016, 6, 28115.
                    • Arabski M, Barabanova A, Ga┼éczy┼äska K, W─Ögierek-Ciuk A, Dzidowska K, Augustyniak D, Drulis-Kawa Z, Lankoff A, Yermak I, Molinaro A, Kaca W. Modification biological activity of S and R forms of Proteus mirabilis and Burkholderia cepacia lipopolysaccharides by carrageenans. Carbohydr Polym. 2016, 149, 408-414.

                    2015

                    • Danis-Wlodarczyk K, Olszak T, Arabski M, Wasik S, Majkowska-Skrobek G, Augustyniak D, Gula G, Briers Y, Jang HB, Vandenheuvel D, Duda KA, Lavigne R, Drulis-Kawa Z. Characterization of the newly isolated lytic bacteriophages KTN6 and KT28 and their efficacy against Pseudomonas aeruginosa biofilm. PLoS One 2015, 21;10(5):e0127603.
                    • Arabski M, Konieczna I, Tusi┼äska E, W─ůsik S, Relich I, Zaj─ůc K, Kami┼äski ZJ, Kaca W. The use of lysozyme modified with fluorescein for the detection of Gram-positive bacteria. Microbiol. Res. 2015, 170, 242-247.
                    • Ga┼éczy┼äska K, Kurdziel K, Adamus-Bia┼éek W, W─ůsik S, Szary K, Drabik M, W─Ögierek-Ciuk A, Lankoff A, Arabski M. The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis. Acta Biochim. Pol. 2015, 62, 739-745.
                    • Wegierek-Ciuk A, Arabski M, Kedzierawski P, Florek A, Solowiej D, Gozdz S, Lisowska H, Kowalik A, Kowalska M, Wojcik A, Polanska J, Lankoff A. Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, ╬│-H2AX foci, polymorphisms in DNA repair genes and apoptosis. Journal of Pre-Clinical and Clinical Research 2015, 9, 97-104.

                    2014

                    • W─ůsik S, Arabski M, Dworecki K, Janoska J, Semaniak J, Szary K, Sl─Özak A. Laser interferometric analysis of glucose and sucrose diffusion in agarose gel. Gen Physiol Biophys. 2014 , 33, 383-391.
                    • Czerwonka G, Arabski M, W─ůsik S, Jab┼éo┼äska-Wawrzycka A, Rogala P, Kaca W. Morphological changes in Proteus mirabilis O18 biofilm under the influence of a urease inhibitor and a homoserine lactone derivative. Archives of Microbiology 2014, 196, 169-77.
                    • Piwnik M, Koszto┼éowicz T, W─ůsik S, Lewandowska KD, Klinkosz T, Koszto┼éowicz Z, Arabski M. Subdiffusive model of released substance from a spherical medium. Acta Physica Polonica B 2014, 45, 1907-1913.
                    • W─ůsik S, Arabski M, Maciejec K, Suchanek G, ┼Üwiercz A. Testing sorption properties of halloysite by means of the laser interferometry method. Current Topics in Biophysics 2014, 37, 43-47.
                    • Arabski M, Borowiec A, Banasik P. Dzidowska K. Effect of gentamicin on Pseudomonas aeruginosa PAO1 biofilm under aerobic or microaerophilic conditions. Konferencja DiagMol ÔÇ×Biologia molekularna w diagnostyce chor├│b zaka┼║nych i biotechnologiiÔÇŁ, Warszawa, pa┼╝dziernik 2014, (monografia)

                    2013

                    • Lankoff A, Arabski M, Wegierek-Ciuk A, Kruszewski M, Lisowska H, Banasik-Nowak A, Rozga-Wijas K, Wojewodzka M, Slomkowski S.Effect of surface modification of silica nanoparticles on toxicity and cellular uptake by human peripheral blood lymphocytes in vitro. Nanotoxicology 2013, 7, 235-50.
                    • Arabski M, Lisowska H, Lankoff A, Davydova VN, Drulis-Kawa Z, Augustyniak D, Yermak IM, Molinaro A, Kaca W. The properties of chitosan complexes with smooth and rough forms of lipopolysaccharides on CHO-K1 cells. Carbohydr Polym. 2013, 97, 284-292.
                    • W─ůsik S, Arabski M, Drulis-Kawa Z, Gubernator J. Laser interferometry analysis of ciprofloxacin and ampicillin diffusion from liposomal solutions to water phase. Eur Biophys J. 2013, 42, 549-558.
                    • Arabski M, W─ůsik S, Zych M, ┼üakomiec W, Kaca W. Analysis of ciprofloxacin and gentamicin diffusion in Proteus mirabilis O18 biofilm by laser interferometry method. Acta Biochim Pol 2013, 60, 707-711.
                    • Arabski M, W─ůsik S, Drulis-Kawa Z. Laser interferometry analysis of ciprofloxacin diffusion through Pseudomonas aeruginosa biofilm. Clin Microbial 2013, 2:2.
                    • Arabski M. Laser interferometric method in the measurement of lipopolysaccharides interactions with antibacterial compounds. Clin Microbial 2013, 2:1.
                    • Arabski M, Kubicka K, Kaca W. Analysis of nickel binding by P. mirabilis cells ÔÇô the role of lipopolysaccharides. Konferencja DiagMol ÔÇ×Biologia molekularna w diagnostyce chor├│b zaka┼║nych i biotechnologiiÔÇŁ, Warszawa, 19 listopad 2013, str. 44-46. (monografia).

                    2012

                    • Arabski M, Fuda┼éa R, W─ůsik S, Koza A, Futoma-Ko┼éoch B, Bugla-P┼éosko┼äska G, Kaca W (2012) The presence of anti-LPS antibodies, human serum activity against P. mirabilis S/R forms and TLR4 (Thr399Ile) gene polymorphism in rheumatoid arthritis. Clin Biochem. 45, 1374-1382.
                    • Arabski M, W─Ögierek-Ciuk A, Czerwonka G, Lankoff A, Kaca W (2012) Effects of saponins against clinical E. coli strains and eukaryotic cell line. J. Biomed. Biotechnol. Article ID 286216.
                    • Arabski M, W─ůsik S, Grze┼Ťkiewicz H, Drulis-Kawa Z, Gubernator J, Kaca W (2012) Laser interferometric determination of liposome diffusion through artificial membranes, Chapter 14 in the monograph entitled Interferometry ÔÇô Research and Applications in Science and Technology, ISBN: 978-953-51-0403-2
                    • Arabski M, W─ůsik S, Piskulak P, Czerwonka G, Kaca W (2012) Analysis of nickel chloride diffusion through Proteus mirabilis biofilm. DiagMol XIII Warsaw, Poland (evaluated article).
                    • Koszto┼éowicz T, Lewandowska K.D, Arabski M, W─ůsik S (2012) The theoretical model of a released substance from a subdiffusive membrane to a diffusive environment. XVIII Krajowa Konferencja Zastosowa┼ä Matematyki w Biologii i Medycynie (evaluated article).

                    2011

                    • Arabski M, W─ůsik S, Piskulak P, G├│┼║d┼║ N, ┼Ül─Özak A, Kaca W (2011) Analysis of antibiotic diffusion from agarose gel with spectrophotometry and laser interferometry methods. (article in Polish) Polim Med. 41, 25-32.
                    • Arabski M, W─ůsik S, Kaca W (2011) The application of laser interferometry in microbiology. DiagMol XII Warsaw, Poland (evaluated article).

                    2010

                    • W─ůsik S, Arabski M, Dworecki K, Kaca W, ┼Ül─Özak A (2010) Influence of gravitational field on the substance transport in gels. J. Membrane Sci. 365, 341-346.
                    • Arabski M, Konieczna I, So┼éowiej D, Rogo┼ä A, Kolesi┼äska B, Kami┼äski Z, Kaca W (2010) Are anti-H. pylori urease antibodies involved in atherosclerotic diseases. Clin. Biochem. 43, 115-123.

                    2009

                    • Arabski M, Davydova VN, W─ůsik S, Reunov AV, Lapshina LA, Solov`eva TF, Yermak I M, Kaca W (2009) Binding and biological properties of lipopolysaccharide Proteus vulgaris O25 (48/57)-chitosan complexes. Carbohydr. Polym. 78, 481-487.
                    • Arabski M, W─ůsik S, Dworecki K, Kaca W (2009) Laser interferometric and cultivation methods for measurement of colistin/ampicillin and saponin interactions with smooth and rough of Proteus mirabilis lipopolysaccharides and cells. J. Microbiol. Methods. 77, 179-183.
                    • W─Ögierek-Ciuk A, Lankoff A, Lisowska H, Banasik-Nowak A, Arabski M, Kedzierawski P, Florek A, W├│jcik A (2009) Chromosomal radiosensitivity in lymphocytes of cervix cancer patients-correlation with side effect after radiotherapy. chapter in Nuclear Physics Methods and Accelerators in Biology and Medicine. ISBN: 978-0-7354-0741-1
                    • Kaca W, Arabski M, Fuda┼éa R, Holmstr├Âm E, Sj├Âholm A, Weintraub A, Futoma-Ko┼éoch B, Bugla-P┼éosko┼äska G, Doroszkiewicz W (2009) Human complement activation by smooth and rough Proteus mirabilis strains: the role of lipopolysaccharides and outer membrane proteins Arch. Immunol. Ther. Exp. (Warsz.) 57, 383-391.

                    2008

                    • Arabski M, Koza A, Kaca W (2008) The chemical structure of Helicobacter pylori lipopolysaccharide and innate immune response. (article in Polish) Postepy Hig. Med. Dosw. 62, 290-298.
                    • Arabski M, W─ůsik S, Dworecki K, Kaca W (2008) Laser interferometric determination of ampicilin diffusion through polyacrylamide gel. chapter in the monograph entitled Membrany i Procesy Membranowe w Ochronie ┼Ürodowiska, 49:63-68.
                    • Nowak A, Arabski M, Libudzisz Z (2008) Ability of intestinal lactic bacteria to bind or/and metabolise indole. Food Technology and Biotechnology 46, 299-304.
                    • Arabski M, Gwo┼║dzi┼äski K, Sudak B, Kaca W (2008) Effects of Proteus mirabilis lipopolysaccharides with different O-polysaccharide structures on the plasma membrane of human erythrocytes, Z. Naturforsch. C, 63, 460-468.
                    • Arabski M, Grabowski S, Konieczna I, Kaca W, Kondakova AN, Perepelov A, Shashkov AS, Knirel YA (2008) Serotyping of clinical isolates belonging to Proteus mirabilis serogroup O36 and structure elucidation of the O36-antigen polysaccharide. FEMS Immunol. Med. Microbiol. 5, 395-403.

                    2007

                    • Arabski M, W─ůsik S, Dworecki K, Kaca W (2007) Laser interferometric determination of ampicillin and colistin transfer through cellulose biomembrane in the presence of Proteus vulgaris O25 lipopolysaccharide. J. Membrane Sci. 299, 268-275.

                    2006

                    • Majsterek I, Arabski M, Czechowska A, Pytel D, Morawiec Z, Morawiec-Bajda A, B┼éasiaka J (2006) Imatinib (STI571) inhibits DNA repair in human leukemia oncogenic tyrosine kinase-expressing cells. Z. Naturforsch. C 61, 896-902.
                    • Arabski M, Ka┼║mierczak P, Wi┼Ťniewska-Jarosi┼äska M, Morawiec Z, Morawiec-Bajda A, Klupi┼äska G, Chojnacki J, B┼éasiak J (2006) Helicobacter pylori infection can modulate the susceptibility of gastric mucosa cells to MNNG. Cell. Mol. Biol. Lett. 11, 570-578.
                    • Pop┼éawski T, Arabski M, Kozirowska D, Morawiec M, Morawiec Z, Morawiec-Bajda A, Klupi┼äska G, Jeziorski A, Chojnacki J, B┼éasiak J (2006) DNA damage and repair in gastric cancer ÔÇô a correlation with the hOGG1 and RAD51 genes polymorphisms. Mutat. Res. 601, 83-91.

                    2005

                    • Arabski M, Ka┼║mierczak P, Wi┼Ťniewska-Jarosi┼äska M, Pop┼éawski T, Klupi┼äska G, Chojnacki J, Drzewoski J, B┼éasiak J (2005) Interaction of amoxicillin with DNA in human lymphocytes and H. pylori-infected and non-infected gastric mucosa cells. Chem. Biol. Interact. 152, 13-24.
                    • Arabski M, Klupi┼äska G, Chojnacki J, Ka┼║mierczak P, Wi┼Ťniewska-Jarosi┼äska M, Drzewoski J, B┼éasiak J (2005) DNA damage and repair in Helicobacter pylori-infected gastric mucosa cells. Mutat. Res. 570, 129-135.

                    2004

                    • B┼éasiak J, Arabski M, Krupa R, Wo┼║niak K, Zadro┼╝ny M, Kasznicki J, ┼╗urawska M, Drzewoski J (2004) DNA damage and repair in type 2 diabetes mellitus. Mutat. Res. 554, 297-304.
                    • B┼éasiak J, Arabski M, Krupa R, Wo┼║niak K, Ryka┼éa J, Ko┼éaci┼äska A, Morawiec Z, Drzewoski J, Zadro┼╝ny M (2004) Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer. Mutat. Res. 554, 139-148.
                    • Wo┼║niak K, Arabski M, Ma┼éecka-Panas E, Drzewoski J, B┼éasiak J (2004) DNA damage in human colonic mucosa cells induced by bleomycin and the protective action of vitamin E. Cell. Mol. Biol. Lett. 9, 31-45.

                    2003

                    • Arabski M, B┼éasiak J (2003) Molekularne aspekty infekcji wywo┼éanej Helicobacter pylori. Post. Biol. Kom. 4: 679-694.

                    2002

                    • B┼éasiak J, Arabski M, Perty┼äski T, Ma┼éecka-Panas E, Wo┼║niak K, Drzewoski J (2002) DNA damage in human colonic mucosa cells evoked by nickel and protective action of quercetin ÔÇô involvement of free radicals? Cell. Biol. Toxicol. 18, 279-288.